Evaluation of antitumor potential of Cu(II) complex with hydrazone of 2-acetylthiazole and Girard’s t reagent

In this paper, the previously synthesized Cu(II) complex ([CuL1(N3) (CH3OH)]BF4) with N,N,N-trimethyl-2-oxo-2-(2-(1-(thiazol-2-yl)ethylidene)- hydrazinyl)ethan-1-aminium chloride, has been characterized and its biological activity studied in detail. The consists of ligand coordinated a deprotonated, formally neutral zwitter-ionic form, via NNO atoms, one azido methanol molecule. was selected due to results cytotoxic activity, brine shrimp test DPPH radical scavenging which were performed. effects on cell cycle phase distribution cervical adenocarcinoma HeLa cells investigated order examine mechanisms anticancer activity. measurement intracellular ROS levels HaCaT lines evaluated explore their possible generation role anti-invasive anti-angiogenic properties evaluated. DNA binding experiments, including fluorescence displacement study cleavage performed obtain information type DNA-metal interactions.